EPA Opens Glyphosate Public Comment Period : In support of the continuing registration review of the popular herbicide, the U.S. Environmental Protection Agency (EPA) has made available an open literature search on glyphosate. The goal of the search is to provide information for an updated glyphosate human health risk assessment, which the EPA anticipates finishing in late 2026.

As part of the process, EPA is asking the public and stakeholders to examine the scientific literature the Agency has discovered and submit any pertinent, peer-reviewed research that might have been missed.

Systematic Review of Scientific Literature

Glyphosate is being reevaluated by the EPA’s Office of Pesticide Programs (OPP) as part of the pesticide registration review process, which is carried out to make sure that registered pesticides continue to satisfy relevant legal requirements as scientific knowledge and information advance.

To find potentially pertinent research, EPA searches the available scientific literature in addition to regulatory guideline studies and other studies submitted to support pesticide registrations. Due to the abundance of independently published scientific papers on glyphosate, EPA has previously performed numerous literature searches.

The Agency has now finished a second thorough search of the literature, concentrating on more recent works that are pertinent to the risk assessment for human health.

The search document outlines EPA’s search methodology, including the databases and search terms utilized, the inclusion and exclusion criteria, and the multi-step procedure for evaluating studies for relevance and quality. An attached spreadsheet compiles papers found during the various search attempts, including studies submitted during earlier public comment sessions.

EPA Seeks Stakeholder Input

Stakeholders have the chance to find pertinent peer-reviewed research that are not found in EPA’s literature search results during the current comment period.

In particular, EPA is looking for data that might be useful for the next revised human health risk assessment. Submitted studies must be publicly available, including the paper or study report and any supporting data, in order to be taken into consideration.

Commentors are asked to include full citation information for any further research, such as:

• The author
• Date of publication
• The title of the journal
• Title of article or study

Key Deadline

Comments are due by September 24, 2026, at the latest, from interested parties and stakeholders.

Comments must be filed via the U.S. government’s regulations portal and should make reference to Docket ID.

What This Means for the Agrochemical Industry

Pesticide manufacturers, registrants, researchers, agricultural stakeholders, and regulatory experts have a significant chance to make sure that pertinent scientific evidence is taken into account during glyphosate’s ongoing registration review thanks to the EPA’s most recent action.

The revised human health risk assessment, which is expected to be finished by late 2026, might help the EPA make future glyphosate-related regulatory decisions. Therefore, before the September 24 deadline, stakeholders with pertinent peer-reviewed research should examine the Agency’s literature compilation and submit any additional studies that qualify.

This comment period offers regulatory experts and glyphosate stakeholders a timely chance to make sure the scientific evidence base taken into consideration by EPA is as comprehensive and up-to-date as feasible.